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+++Breaking News: Important publications on COVID-19

The COVID-19 epidemic is multifactorial but diet has not been sufficiently considered in severity. Geographic differences in COVID-19 mortality suggest the importance of diet. Clinical studies in three patients have contributed to developing a proof-of-concept for the hypothesis that combined Nrf2-TRPA1 foods may be beneficial for some COVID-19 symptoms.

Latest Publication in 2021: Reactivation of mild COVID-19 symptoms after vaccination during long COVID-19 and immediate control by nutrients and acetylleucine: Clinical case report

Authors: Jean Bousquet, Wienczyslawa Czarlewski, Vincent Le Moing, Hubert Blain, Jacques Reynes, Anna Bedbrook, Torsten Zuberbier, Josep M Anto.

Latest Publication: Paracetamol low dose, broccoli seeds, curcumin and black pepper capsules control some but not all symptoms of COVID-19

Authors: Jean Bousquet, MD Charité, Universitätsmedizin Berlin, Humboldt-Universität zu Berlin, and Berlin Institute of Health, Comprehensive Allergy Center, Department of Dermatology and Allergy, Berlin, Germany. MACVIA-France,  Montpellier, France.,Wienczyslawa Czarlewski, MD, Medical Consulting Czarlewski, Levallois, France, MASK-air, Montpellier, France., Torsten Zuberbier, MD, Charité, Universitätsmedizin Berlin, Humboldt-Universität zu Berlin, and Berlin Institute of Health, Comprehensive Allergy Center, Department of Dermatology and Allergy, Berlin, Germany., Frederico Regateiro, MD, Allergy and Clinical Immunology Unit, Centro Hospitalar e Universitário de Coimbra, Coimbra and Institute of Immunology, Faculty of Medicine, University of Coimbra, Coimbra, Portugal., Guido Iaccarino, MD, Department of Advanced Biomedical Sciences, Federico II University, Napoli, Italy., Hubert Blain, MD, Department of Geriatrics, Montpellier University Hospital,  Montpellier, France., Josep Anto, MD, IMIM (Hospital del Mar Research Institute), Barcelona, Spain, CIBER Epidemiología y Salud Pública (CIBERESP), Barcelona, Spain, ISGlobAL, Barcelona Institute for Global Health, Barcelona, Spain.

Latest Publication: N-of-1 trial of serial induced cough challenges in COVID-19 showing an interplay between Nrf2, TRPA1 and TRPV1 agonists

Background: COVID-19 is commonly associated with impaired redox homeostasis responsible for reactive oxygen species accumulation. Antioxidants have been proposed as being effective in controlling
COVID-19 symptoms. Nuclear factor (erythroid-derived 2)-like 2 (Nrf2) is the most effective antioxidant mechanism. TRPA1 (transient receptor potential ankyrin 1) is highly sensitive to oxidative stress and induces several COVID-19 symptoms. TRPA1 and TRPV1 (transient receptor potential
vanillin 1) are potential candidates for COVID-19 symptoms.

Latest Publication: Kimchi, a possible food prototype for the control of COVID-19 by nutrients due to an interplay between Nrf2, TRPA1 and TRPV1

Jean Bousquet, Wienczyslawa Czarlewski, Torsten Zuberbier, Anna Bedbrook, Hubert Blain, Josep M Anto. Berlin, Montpellier, Levallois and Barcelona.
Key words: COVID-19, Kimchi, Nrf2, TRPA1, TRPV1, capsaicin, oxidative stress

Latest Publication: Induced cough challenges in a single patient with COVID-19 showing an interplay between Nrf2, TRPA1 and TRPV1 agonists

COVID-19 is commonly associated with impaired redox homeostasis responsible for reactive oxygen species acumulation. Antioxidants have been proposed as being effective in controlling COVID-19 symptoms. Nuclear factor (erythroid-derived 2)-like 2 (Nrf2) is the most effective
antioxidant mechanism. TRPA1 (transient receptor potential ankyrin 1) is highly sensitive to oxidative stress and induces several COVID-19 symptoms. TRPA1 and TRPV1 (transient receptor potential vanillin 1) are potential candidates for COVID-19 symptoms.

Jean Bousquet 1-2, Wienczyslawa Czarlewski 3,4, Torsten Zuberbier 1, Joaquim Mullol 5, Hubert Blain 6, Rafael de la Torre 8-10, Josep M Anto 9-13

A common denominator in all conditions associated with COVID-19 appears to be the oxidative stress storm. Antioxidant nutrients may be of importance in COVID-19 through Nrf2 activation. TRP (Transient Receptor Potential) desensitization has been suggested in 6 COVID-19 patients since broccoli capsules (potent Nrf2 and weak TRPA1 agonist) reduced cough and nasal obstruction within 10-20 minutes. A series of cough induced challenges were carried out in one COVI-19 patient. Curcuma and black pepper, ginger or green tea all improved cough and nasal obstruction in less than 2 minutes.

Jean Bousquet, Wienczyslawa Czarlewski, Torsten Zuberbier, Joaquim Mullol, Hubert Blain, Anna Bedbrook, Piotr Kuna, Josep M Anto

Jean Bousquet (1-3), Jean-Paul Cristol (4), Wienczyslawa Czarlewski (5-6), Josep M Anto (7-10), Adrian Martineau (11), Tari Haahtela (12), Susana C Fonseca (13), Guido Iaccarino (14), Hubert Blain (15), Alessandro Fiocchi (16), G Walter Canonica (17), Joao A Fonseca (18), Alain Vidal (19), Hak-Jong Choi (20), Hyun Ju Kim (21), Vincent Le Moing (22), Jacques Reynes (22), Aziz Sheikh (23), Cezmi A Akdis (24), Torsten Zuberbier(1), and the ARIA group

  • 8. Clinical case Efficacy of broccoli and glucoraphanin in COVID-19: From hypothesis to proof-of-concept with three experimental cases Jean Bousquet 1-2, Vincent Le Moing 3, Hubert Blain 4, Wienczyslawa Czarlewski 5,6, Torsten Zuberbier 1, Raphael de la Torre8,9,10, Nieves Pizarro Lozano9, Jacques Reynes 3, Anna Bedbrook 2,6, Jean-Paul Cristol 7, Alvaro A. Cruz13, Alessandro Fiocchi 14, Tari Haahtela 15, Guido Iaccarino16, Ludger Klimek 17, Piotr Kuna 18, Eric Melèn 19, Joaquim Mullol 20, Boleslaw Samolinski 21, Arunas Valiulis 22, Josep M Anto 9-12

Is diet partly responsible for differences in COVID-19 death rates between and within countries

(1MB)The full paper “Is diet partly responsible for differences in COVID-19 death rates between and within countries? “is available here. Bousquet et al. Clin Transl. Allergy (2020) 10:16 https://doi.org/10.1186/s13601-020-00323-0