GA²LEN Educational events in South Africa
ABSTRACT: Effective continuing education in dermatology for healthcare providers can be supported by various measures such as literature, webinars, online tools and lectures. The Global Allergy and Asthma European Network (GA²LEN) has developed a compact training programme on allergic diseases, including but not limited to atopic dermatitis, alopecia areata, allergic rhinitis, asthma, pruritus, angioedema, urticaria and anaphylaxis and food allergy. In this article we present the impact of and argue for the continuing need for GA²LEN training programmes on the basis of a review of data from the past six global educational programmes. These data indicate the efficacy of ongoing education and the updating of healthcare professionals’ knowledge and the need for continuing education in South Africa.
Important publications on COVID-19
The COVID-19 epidemic is multifactorial but diet has not been sufficiently considered in severity. Geographic differences in COVID-19 mortality suggest the importance of diet. Clinical studies in three patients have contributed to developing a proof-of-concept for the hypothesis that combined Nrf2-TRPA1 foods may be beneficial for some COVID-19 symptoms.
Authors: Jean Bousquet, Wienczyslawa Czarlewski, Vincent Le Moing, Hubert Blain, Jacques Reynes, Anna Bedbrook, Torsten Zuberbier, Josep M Anto.
Authors: Jean Bousquet, MD Charité, Universitätsmedizin Berlin, Humboldt-Universität zu Berlin, and Berlin Institute of Health, Comprehensive Allergy Center, Department of Dermatology and Allergy, Berlin, Germany. MACVIA-France, Montpellier, France.,Wienczyslawa Czarlewski, MD, Medical Consulting Czarlewski, Levallois, France, MASK-air, Montpellier, France., Torsten Zuberbier, MD, Charité, Universitätsmedizin Berlin, Humboldt-Universität zu Berlin, and Berlin Institute of Health, Comprehensive Allergy Center, Department of Dermatology and Allergy, Berlin, Germany., Frederico Regateiro, MD, Allergy and Clinical Immunology Unit, Centro Hospitalar e Universitário de Coimbra, Coimbra and Institute of Immunology, Faculty of Medicine, University of Coimbra, Coimbra, Portugal., Guido Iaccarino, MD, Department of Advanced Biomedical Sciences, Federico II University, Napoli, Italy., Hubert Blain, MD, Department of Geriatrics, Montpellier University Hospital, Montpellier, France., Josep Anto, MD, IMIM (Hospital del Mar Research Institute), Barcelona, Spain, CIBER Epidemiología y Salud Pública (CIBERESP), Barcelona, Spain, ISGlobAL, Barcelona Institute for Global Health, Barcelona, Spain.
Background: COVID-19 is commonly associated with impaired redox homeostasis responsible for reactive oxygen species accumulation. Antioxidants have been proposed as being effective in controlling
COVID-19 symptoms. Nuclear factor (erythroid-derived 2)-like 2 (Nrf2) is the most effective antioxidant mechanism. TRPA1 (transient receptor potential ankyrin 1) is highly sensitive to oxidative stress and induces several COVID-19 symptoms. TRPA1 and TRPV1 (transient receptor potential
vanillin 1) are potential candidates for COVID-19 symptoms.
Jean Bousquet, Wienczyslawa Czarlewski, Torsten Zuberbier, Anna Bedbrook, Hubert Blain, Josep M Anto. Berlin, Montpellier, Levallois and Barcelona.
Key words: COVID-19, Kimchi, Nrf2, TRPA1, TRPV1, capsaicin, oxidative stress
COVID-19 is commonly associated with impaired redox homeostasis responsible for reactive oxygen species acumulation. Antioxidants have been proposed as being effective in controlling COVID-19 symptoms. Nuclear factor (erythroid-derived 2)-like 2 (Nrf2) is the most effective
antioxidant mechanism. TRPA1 (transient receptor potential ankyrin 1) is highly sensitive to oxidative stress and induces several COVID-19 symptoms. TRPA1 and TRPV1 (transient receptor potential vanillin 1) are potential candidates for COVID-19 symptoms.
Jean Bousquet 1-2, Wienczyslawa Czarlewski 3,4, Torsten Zuberbier 1, Joaquim Mullol 5, Hubert Blain 6, Rafael de la Torre 8-10, Josep M Anto 9-13
A common denominator in all conditions associated with COVID-19 appears to be the oxidative stress storm. Antioxidant nutrients may be of importance in COVID-19 through Nrf2 activation. TRP (Transient Receptor Potential) desensitization has been suggested in 6 COVID-19 patients since broccoli capsules (potent Nrf2 and weak TRPA1 agonist) reduced cough and nasal obstruction within 10-20 minutes. A series of cough induced challenges were carried out in one COVI-19 patient. Curcuma and black pepper, ginger or green tea all improved cough and nasal obstruction in less than 2 minutes.
Jean Bousquet, Wienczyslawa Czarlewski, Torsten Zuberbier, Joaquim Mullol, Hubert Blain, Anna Bedbrook, Piotr Kuna, Josep M Anto
- Oral capsaicin induces a very fast improvement in COVID-19 symptoms suggesting TRPV1 channel desensitization
- TRPA1 and COVID 141020 Potential control of COVID-19 symptoms by Nrf2-interacting nutrients with TRPA1 (transient receptor potential ankyrin 1) agonist activity Jean Bousquet, Wienczyslawa Czarlewski, Torsten Zuberbier, Joaquim Mullol, Hubert Blain, Raphael de la Torre Anna Bedbrook, Alessandro Fiocchi, Tari Haahtela, Ludger Klimek, Piotr Kuna, Nikolaos Papadopoulos, Aziz Sheikh, Arunas Valiulis, Josep M Anto
- COVID-19: Why Germany’s case fatality rate seems so low
- Covid-diet CTA
- Association fermented foods
- Cabbage and fermented vegetables: From death rate heterogeneity in
countries to candidates for mitigation strategies of severe COVID‐19
- Nrf2 nutrients Nrf2-TPRA1 interacting nutrients, insulin resistance and COVID-19: Time for research to develop mitigation strategies
Jean Bousquet (1-3), Jean-Paul Cristol (4), Wienczyslawa Czarlewski (5-6), Josep M Anto (7-10), Adrian Martineau (11), Tari Haahtela (12), Susana C Fonseca (13), Guido Iaccarino (14), Hubert Blain (15), Alessandro Fiocchi (16), G Walter Canonica (17), Joao A Fonseca (18), Alain Vidal (19), Hak-Jong Choi (20), Hyun Ju Kim (21), Vincent Le Moing (22), Jacques Reynes (22), Aziz Sheikh (23), Cezmi A Akdis (24), Torsten Zuberbier(1), and the ARIA group
- 8. Clinical case Efficacy of broccoli and glucoraphanin in COVID-19: From hypothesis to proof-of-concept with three experimental cases Jean Bousquet 1-2, Vincent Le Moing 3, Hubert Blain 4, Wienczyslawa Czarlewski 5,6, Torsten Zuberbier 1, Raphael de la Torre8,9,10, Nieves Pizarro Lozano9, Jacques Reynes 3, Anna Bedbrook 2,6, Jean-Paul Cristol 7, Alvaro A. Cruz13, Alessandro Fiocchi 14, Tari Haahtela 15, Guido Iaccarino16, Ludger Klimek 17, Piotr Kuna 18, Eric Melèn 19, Joaquim Mullol 20, Boleslaw Samolinski 21, Arunas Valiulis 22, Josep M Anto 9-12
Is diet partly responsible for differences in COVID-19 death rates between and within countries
(1MB)The full paper “Is diet partly responsible for differences in COVID-19 death rates between and within countries? “is available here. Bousquet et al. Clin Transl. Allergy (2020) 10:16 https://doi.org/10.1186/s13601-020-00323-0